Rockefeller University

Introduction to Drug Discovery: Basics of Small Molecule and Biologics Drug Discovery and Development

Join scientists from the Sanders Tri-Institutional Therapeutics Discovery institute as they share their broad knowledge of small molecule and biologics drug discovery. This mini-course will be provided in four sessions over the course of three weeks.

The course covers:

An overview of Sanders TDI
Target identification and validation
Assays for drug discovery
Assay development
Screening methodologies
Introduction to medicinal chemistry
Introduction to computational chemistry and molecular modeling
Antibody generation strategies
Immunization strategies
Antibody engineering and optimization
Developability assessment

WCM drug discovery course flyer.pdf

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Select Session

SMALL MOLECULE DRUG DISCOVERY

Availability - Open

Biology for Small Molecule Drug Discovery

High level overview of the drug discovery process and strategic introduction to thinking about drug discovery. Academic science and biotech science are quite different. Learn about these differences from two academically trained biologists who have transitioned to careers in drug discovery! topics include: What do you need to start a drug discovery program? How should you think about target validation? What kind of screening is most likely to give you good hits? How do you optimize an assay for screening? What are the best practices for profiling compounds? and more...

Date -	Monday April 01, 2024
Time:	1:00 pm - 3:00 pm
Location:	1305 York WGC-B/C 2nd floor
Instructor -	Leigh Baxt and Efrat Finkin-Groner
Contact -	Leigh Baxt lbaxt@titdi.org

Availability - Open

Introduction to Medicinal and Computational Chemistry

Intro to med chem and comp chem for biologists. Learn how chemists can modify and optimize molecules using molecular and computational tools to improve properties and make a molecule more drug-like. This session will cover the work that happens between identifying a screen hit and being ready to dose an animal to prove your biological hypothesis. Presented at a level requiring no chemistry background!

Date -	Tuesday April 02, 2024
Time:	1:00 pm - 3:00 pm
Location:	1305 York WGC-B/C 2nd floor
Instructor -	John Ginn and David Huggins
Contact -	Leigh Baxt lbaxt@titdi.org

BIOLOGICS DISCOVERY AND DEVELOPMENT

Availability - Open

Biologics Discovery

Learn about the differences between Biologics and Small Molecule. What kinds of mechanisms can Biologics have? How do you select an immunization strategy? What kinds of assays are needed for triaging and profiling antibody candidates? How do you optimize assays for Biologics?

Date -	Monday April 08, 2024
Time:	1:00 pm - 3:00 pm
Location:	1305 York WGC-B/C 2nd floor
Instructor -	Paul Balderes and Irina Lebedeva
Contact -	Leigh Baxt lbaxt@titdi.org

Availability - Waiting List

Antibody Engineering and Bioanalytics

How can Biologics be optimized to become therapeutics? Learn about lead optimization and evaluating developability of Biologics in this session.

Date -	Monday April 15, 2024
Time:	1:00 pm - 3:00 pm
Location:	Belfer Research Building 302C
Instructor -	Elisabeth Nyakatura and Olivia Vergnolle
Contact -	Leigh Baxt lbaxt@titdi.org